Abstract:
Abstract
The cytochrome P450 (CYP) 3A family is involved in the elimination processes of almost
50% of commonly used drugs. CYP3A mRNA expressions in goat and rat gastrointestinal
tracts in comparison to the liver were investigated using real-time PCR. In goats, the
expression of CYP3A-like mRNAs was comparatively higher in the liver than in the
gastrointestinal tract. The intestinal expression of CYP3A-like mRNA showed a gradual
decrease from the duodenum to the ileum. In rats, the highest CYP3A62 mRNA expression
was found in the duodenum followed by the liver. This study provides insights into the
contribution of CYP3A enzymes to xenobiotic metabolism, especially in small ruminants
