MMARAU Institutional Repository

Microbiome Structural and Functional Interactions across Host Dietary Niche Space

Show simple item record

dc.contributor.author Phillips, Caleb D.
dc.contributor.author Hanson, John
dc.contributor.author Wilkinson, Jeremy E.
dc.contributor.author Koenig, Lawrence
dc.contributor.author Rees, Eric
dc.contributor.author Webala, Paul
dc.contributor.author Kingston, Tigga
dc.date.accessioned 2018-05-14T14:53:42Z
dc.date.available 2018-05-14T14:53:42Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/123456789/6756
dc.description.abstract Host-associated microbiomes are integral components of host health, but microbiome community structure varies among and within hosts. Reconciling community variability with the apparent dependence of hosts on community function, and characterizing how functional divergence proceeds across niches, remains challenging. Here, through the study of gut microbiomes and diets of three insectivorous bat species we characterize how community structure is shaped by predicted functional properties of community members. We found that while host diet and microbiome community composition do not significantly relate to each other, host diet and metagenome function do, suggesting that diet directly selects metagenomic functions rather than communities. We use a novel inference framework to show how the discordance between community structure and functional variation derives from functional equivalence and is influenced by the continuum of shared and derived gene sets across microbial lineages. Our findings help clarify how metagenome community structure–function relationships contribute to deterministic processes in community assembly, and describe the basis for metagenomic differences across ecologically similar hosts. en_US
dc.language.iso en en_US
dc.title Microbiome Structural and Functional Interactions across Host Dietary Niche Space en_US
dc.type Learning Object en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account