Abstract:
The naked mole rat has unique biologic characteristics that include atypical infammatory responses. Lipopolysaccharide
induces infammation which triggers brain centers controlling feeding, and behavior to result in “sick animal behavior”. We
characterized the bodyweight, locomotor, and other behavioral responses of this rodent to lipopolysaccharide administration.
Lipopolysaccharide caused weight losses, which were not prevented by TAK 242. In the open feld test, lipopolysaccharide
did not depress locomotion, while urination, defecation, and activity freezing were rare. The animals exhibited walling but
not rearing and fast backward movements that were unafected by lipopolysaccharide. Failure to depress locomotion suggests
either a unique immunity-brain crosstalk or motor responses/centers that tolerate depressive efects of infammation. The
absence of activity freezing and rarity of urination and defecation suggests that novel environments or lipopolysaccharide do
not induce anxiety, or that anxiety is expressed diferently in the animal. The absence of rearing could be due to the design
of the animal’s locomotor apparatus while fast backward movement could be a mechanism for quick escape from threats in
the tunnels of their habitat. Our results elucidate the unique biology of this rodent, which elicits interest in the animal as a
model for infammatory research, although the fndings require mechanistic corroborations.
